And now that the vaccine has been given to more than 10 million people, I think you can say with some confidence that there doesn't appear to be right now a very rare, serious side effect that would be something that would cause a long-term problem. So I think in those preapproval studies where the vaccines have been tested in tens of thousands of people, you could say with confidence that there wasn't at least a relatively uncommon, serious side effect.
So, although some of those effects are long term like polio or narcolepsy, they're still picked up within six weeks. That's why it is that the FDA, the Food and Drug Administration, insisted that each of these vaccines be studied for at least two months after the last dose, knowing that there's not been a serious side effect in history that hasn't occurred within weeks of getting the dose, within six weeks of getting the dose. The good news about these terrible side effects is that they all occur within six weeks of a dose. And, measles-containing vaccine can cause a lowering of the platelet count, which can cause these sort of like broken blood vessels called petechiae again, occurred in maybe 1 in 30,000 people - rare but real. There was a squalene adjuvanted influenza vaccine that was used in Europe that was also a very rare cause of something called narcolepsy, which is a permanent disorder of wakefulness. Yellow fever vaccine was a rare cause of something that had the fancy name viscerotropic disease, which is really basically a form of yellow fever again, occurred in about 1 in a million people it was rare, but it was real. So for example, vaccines like the oral polio vaccine was a rare cause of polio it occurred in maybe 1 per 2.4 million people, but it was real. Well, vaccines like any medical product that have a positive effect can have a negative effect, and that's true here too.
It is January 2021, and now in the midst of this pandemic, and now with the advent of two new vaccines, so-called messenger RNA vaccines to prevent SARS-CoV-2, people ask the reasonable question: Since this is a new strategy, a new way to make a vaccine, what are the long-term effects? How are we going to know about the long-term effects?
My name is Paul Offit from the Vaccine Education Center. What are the long-term side effects of COVID-19 vaccine?
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